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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

1. An immunocompromised patient develops a disseminated fungal infection. Blood cultures are negative, but a serum galactomannan assay is strongly positive. A CT scan of the chest reveals multiple nodular lesions with a halo sign. Bronchoalveolar lavage (BAL) fluid is analyzed by PCR, yielding a positive result for Aspergillus fumigatus. The halo sign observed on the CT scan is primarily attributed to:

A) Formation of thick-walled cysts containing fungal conidia.
B) Extensive granuloma formation surrounding fungal hyphae.
C) A hypersensitivity reaction in the lung parenchyma.
D) Angioinvasion by Aspergillus hyphae leading to localized hemorrhage and necrosis.

2. A clinical isolate of Klebsiella pneumoniae from a patient with a refractory urinary tract infection exhibits resistance to carbapenems (imipenem, meropenem, ertapenem). PCR analysis reveals the presence of the blaKPC gene. Which of the following enzymatic mechanisms is responsible for this resistance?

A) Trapping of the carbapenem molecule by a decoy protein.
B) Hydrolysis of the beta-lactam ring, leading to an inactive antibiotic derivative.
C) Efflux of the carbapenem antibiotic out of the bacterial cell.
D) Modification of the ribosomal target site, preventing antibiotic binding.

3. Chagas disease, characterized by acute Romana's sign and potential chronic cardiac and gastrointestinal complications, is caused by which vector-borne protozoan parasite?

A) Leishmania donovani
B) Toxoplasma gondii
C) Trypanosoma cruzi
D) Trypanosoma brucei gambiense

4. A fungal isolate grown from a blood culture at 37°C shows budding yeast cells. When subcultured to cornmeal agar with Tween 80 and incubated at 25°C, it produces pseudohyphae and terminal chlamydospores.
Growth on CHROMagar Candida yields green colonies. This organism is most likely:

A) Cryptococcus neoformans
B) Candida parapsilosis
C) Candida albicans
D) Candida glabrata

5. A clinical microbiology laboratory isolates a Gram-negative rod from a wound infection following a dog bite.
The organism grows on MacConkey agar, is oxidase-positive, and produces a characteristic bleach-like odor.
The MOST likely identification is:

A) Bordetella bronchiseptica
B) Pasteurella multocida
C) Pseudomonas aeruginosa
D) Capnocytophaga canimorsus

Solutions: